Abstract
The efficiency of treatment was analyzed in 142 children aged 3-14 years who had local forms of primary pulmonary tuberculosis. Therapy was performed according to regimens 3 and 1, by using individual dosage regimens depending on the extent and severity of a specific process, the presence of complications, and age-related features. In minor tuberculosis, solitary calcifications being detected without signs of the activity of tuberculous infection, the basic course of therapy was 6-8 months; it was performed using 2 drugs in individual cases. In disseminated and complicated processes, eliminated intoxication and visible X-ray inflammatory changes were observed in 58.8-61.7% of children by months 3-4 of treatment, which required a longer intensive phase, by administering 3 drugs in the continuation phase till 6-9 months.
MeSH terms
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Adolescent
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Age Factors
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Antibiotics, Antitubercular / administration & dosage
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Antibiotics, Antitubercular / therapeutic use
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Antitubercular Agents / administration & dosage
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Antitubercular Agents / adverse effects
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Antitubercular Agents / therapeutic use*
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Child
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Child, Preschool
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Cycloserine / administration & dosage
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Cycloserine / therapeutic use
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Drug Therapy, Combination
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Ethambutol / administration & dosage
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Ethambutol / therapeutic use
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Humans
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Isoniazid / administration & dosage
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Isoniazid / therapeutic use
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Prothionamide / administration & dosage
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Prothionamide / therapeutic use
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Pyrazinamide / administration & dosage
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Pyrazinamide / therapeutic use
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Radiography, Thoracic
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Rifampin / administration & dosage
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Rifampin / therapeutic use
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Streptomycin / administration & dosage
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Streptomycin / therapeutic use
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Time Factors
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Tuberculosis, Lymph Node / diagnosis
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Tuberculosis, Lymph Node / drug therapy
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Tuberculosis, Pulmonary / diagnosis
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Tuberculosis, Pulmonary / diagnostic imaging
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Tuberculosis, Pulmonary / drug therapy*
Substances
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Antibiotics, Antitubercular
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Antitubercular Agents
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Pyrazinamide
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Prothionamide
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Ethambutol
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Cycloserine
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Isoniazid
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Rifampin
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Streptomycin