Mononuclear Cu(II)-phenolate bioinspired complex is catalytically promiscuous: phosphodiester and peptide amide bond cleavage

Inorg Chem. 2009 Apr 6;48(7):2711-3. doi: 10.1021/ic802208v.

Abstract

In this work, the cleavage activity of the metal complex [Cu(C(21)H(21)N(3)O(2))(OH(2))(2)](2+) is demonstrated to occur toward double-stranded DNA, in addition to its previously described amide bond cleavage activity, thus suggesting catalytic promiscuity for this complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Catalysis
  • Copper / chemistry*
  • DNA / chemistry
  • Hydrogen-Ion Concentration
  • Organometallic Compounds / chemistry*
  • Organophosphates / chemistry*
  • Osmolar Concentration
  • Peptides / chemistry*
  • Phenols / chemistry*
  • Plasmids / chemistry
  • Temperature

Substances

  • Amides
  • Organometallic Compounds
  • Organophosphates
  • Peptides
  • Phenols
  • Copper
  • DNA