Abstract
For 10 years, a young man was followed for a severe osteoporosis associated with a considerable reduction in height and a massive weight loss. The constant increase of signs of tissue impregnation with thyroid hormones and the molar ratios of alpha-TSH suggested an inappropriate secretion of thyrotropin. Magnetic resonance imaging finally revealed a thyrotropic microadenoma of the pituitary gland. This case gives some new additional information on thyrotropin-induced osteoporosis. To our knowledge such a case has never been reported in the literature.
MeSH terms
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Adult
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Alkaline Phosphatase / blood
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Body Height
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Body Weight
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Bone Density / drug effects
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Calcium / blood
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Calcium / urine
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Carbimazole / therapeutic use
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Diphosphonates / pharmacology
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Diphosphonates / therapeutic use
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Glycoprotein Hormones, alpha Subunit / blood
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Glycoprotein Hormones, alpha Subunit / metabolism
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Humans
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Hydroxyproline / urine
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Hyperthyroidism / blood
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Hyperthyroidism / complications
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Hyperthyroidism / etiology*
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Magnetic Resonance Imaging
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Male
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Octreotide / therapeutic use
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Osteocalcin / blood
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Osteoporosis / blood
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Osteoporosis / drug therapy
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Osteoporosis / etiology*
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Osteoporosis / metabolism*
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Phosphates / blood
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Pituitary Gland / pathology
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Pituitary Gland / surgery
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Pituitary Neoplasms / complications*
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Pituitary Neoplasms / metabolism*
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Pituitary Neoplasms / pathology
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Pituitary Neoplasms / surgery
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Thyrotropin / blood
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Thyrotropin / metabolism*
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Thyroxine / blood
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Triiodothyronine / blood
Substances
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Diphosphonates
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Glycoprotein Hormones, alpha Subunit
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Phosphates
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Triiodothyronine
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Osteocalcin
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Carbimazole
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Thyrotropin
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Alkaline Phosphatase
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Thyroxine
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Hydroxyproline
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Octreotide
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Calcium