Microparticles in endothelial cell and vascular homeostasis: are they really noxious?

Haematologica. 2009 Mar;94(3):313-7. doi: 10.3324/haematol.2009.003657.

Abstract

Endothelial damage and release of membrane microparticles are key steps in the pathogenesis of inflammation. In this perspective article, Dr. Morel and co-workers discuss the biological and clinical significance of microparticles in endothelial cells. See related article on page 387.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Antigens, CD / metabolism
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism*
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects
  • Endothelial Cells / metabolism*
  • Endothelial Protein C Receptor
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiopathology*
  • Homeostasis / drug effects
  • Homeostasis / physiology*
  • Humans
  • Inflammation / prevention & control
  • Models, Biological
  • Particle Size
  • Protein Binding
  • Protein C / metabolism
  • Protein C / pharmacology
  • Receptors, Cell Surface / metabolism
  • Sepsis / prevention & control

Substances

  • Antigens, CD
  • Endothelial Protein C Receptor
  • PROCR protein, human
  • Protein C
  • Receptors, Cell Surface