Abstract
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.
MeSH terms
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry*
-
Antineoplastic Agents / pharmacology
-
Cell Line, Tumor
-
Curcumin / analogs & derivatives*
-
Curcumin / chemical synthesis
-
Curcumin / chemistry
-
Curcumin / pharmacology
-
Drug Screening Assays, Antitumor
-
Female
-
Humans
-
Male
-
Phloroglucinol / analogs & derivatives*
-
Phloroglucinol / chemical synthesis
-
Phloroglucinol / chemistry
-
Phloroglucinol / pharmacology
-
Structure-Activity Relationship
Substances
-
Antineoplastic Agents
-
Phloroglucinol
-
Curcumin