Aspergillus osteomyelitis: review of 12 cases identified by the Prospective Antifungal Therapy Alliance registry

Diagn Microbiol Infect Dis. 2009 Apr;63(4):384-7. doi: 10.1016/j.diagmicrobio.2008.12.005. Epub 2009 Feb 26.

Abstract

A review of 12 patients with proven Aspergillus osteomyelitis was undertaken between July 2004 and October 2007. Aspergillus fumigatus was most commonly identified (n = 9). Voriconazole was commonly administered (11/12; 91.7%), and 9 (75.0%) underwent surgery. Seven (58.3%) responded to treatment, and 12-week mortality was 25.0% (3/12). Survival was improved with surgical intervention (P = 0.05).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antifungal Agents / therapeutic use
  • Aspergillosis / diagnosis*
  • Aspergillosis / drug therapy
  • Aspergillosis / microbiology
  • Aspergillosis / surgery
  • Aspergillus / classification
  • Aspergillus / isolation & purification*
  • Aspergillus fumigatus / classification
  • Aspergillus fumigatus / isolation & purification
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteomyelitis / drug therapy
  • Osteomyelitis / microbiology*
  • Osteomyelitis / mortality
  • Osteomyelitis / surgery
  • Pyrimidines / therapeutic use
  • Treatment Outcome
  • Triazoles / therapeutic use
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole