Effects of visible light-irradiated camphorquinone and 9-fluorenone on murine oral mucosa

Dent Mater J. 2008 Nov;27(6):809-13. doi: 10.4012/dmj.27.809.

Abstract

The purpose of this study was to evaluate the histopathological effects of camphorquinone (CQ) and 9-fluorenone (9F) with or without visible light (VL) irradiation on the oral mucous membranes of mice. VL irradiation resulted in a higher degree of tissue damage after CQ or 9F application, particularly the latter. Necrosis and apoptosis were responsible for the tissue damage after application of either agent in the presence of VL irradiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Cell Nucleus / drug effects
  • Cell Nucleus / ultrastructure
  • Coloring Agents
  • Cytoplasmic Granules / drug effects
  • Cytoplasmic Granules / ultrastructure
  • Cytoplasmic Vesicles / drug effects
  • Cytoplasmic Vesicles / ultrastructure
  • Dental Materials / radiation effects
  • Dental Materials / toxicity*
  • Edema / chemically induced
  • Edema / pathology
  • Epithelial Cells / drug effects
  • Fluorenes / radiation effects
  • Fluorenes / toxicity*
  • Fluorescent Dyes
  • In Situ Nick-End Labeling
  • Light*
  • Materials Testing
  • Mice
  • Mice, Inbred ICR
  • Mouth Mucosa / drug effects*
  • Mouth Mucosa / pathology
  • Necrosis
  • Stomatitis / chemically induced
  • Stomatitis / pathology
  • Terpenes / radiation effects
  • Terpenes / toxicity*

Substances

  • Coloring Agents
  • Dental Materials
  • Fluorenes
  • Fluorescent Dyes
  • Terpenes
  • camphoroquinone
  • 9-fluorenone