One- and two-photon turn-on fluorescent probe for cysteine and homocysteine with large emission shift

Org Lett. 2009 Mar 19;11(6):1257-60. doi: 10.1021/ol802979n.

Abstract

A novel dendritic chromophore with efficient intramolecular charge transfer (ICT) and strong two-photon absorption (TPA) was designed as a turn-on fluorescent probe for cysteine (Cys) and homocysteine (Hcy). The probe exhibited greatly enhanced fluorescence intensity as well as a very large emission peak shift (165 nm) upon addition of Cys/Hcy due to ICT switch off. The sensing process was also monitored by two-photon excited fluorescence (TPEF).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cysteine / analysis
  • Fluorescence
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Homocysteine / analysis
  • Molecular Structure
  • Photons*
  • Polyethylene Glycols / chemistry
  • Structure-Activity Relationship

Substances

  • Fluorescent Dyes
  • Homocysteine
  • Polyethylene Glycols
  • Cysteine