Abstract
The present study was designed to investigate the role of brain adrenergic alpha-2-receptors on feeding regulation of layer-type chicks. Intracerebroventricular injection of the adrenergic alpha-2-receptor agonist, clonidine, stimulated food intake. This effect was blocked by co-injection of the alpha-2-receptor antagonist, yohimbine, demonstrating that the alpha-2-receptor is related to stimulation of feeding in layer-type chicks. Stimulation of food intake caused by neuropeptide Y and beta-endorphin was attenuated by co-injection with yohimbine. However, yohimbine did not block prolactin-releasing peptide stimulation of food intake. It is therefore likely that brain adrenergic alpha-2-receptors mediate the orexigenic effects of neuropeptide Y and beta-endorphin in layer-type chicks.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic alpha-2 Receptor Agonists
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Adrenergic alpha-2 Receptor Antagonists
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Adrenergic alpha-Agonists / pharmacology
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Adrenergic alpha-Antagonists / pharmacology
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Animals
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Chickens / physiology*
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Clonidine / pharmacology
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Eating / drug effects
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Feeding Behavior / drug effects
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Feeding Behavior / physiology*
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Male
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Neuropeptide Y / pharmacology
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Neurotransmitter Agents / pharmacology
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Receptors, Adrenergic, alpha-2 / physiology*
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Yohimbine / pharmacology
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beta-Endorphin / pharmacology
Substances
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Adrenergic alpha-2 Receptor Agonists
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Adrenergic alpha-2 Receptor Antagonists
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Adrenergic alpha-Agonists
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Adrenergic alpha-Antagonists
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Neuropeptide Y
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Neurotransmitter Agents
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Receptors, Adrenergic, alpha-2
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Yohimbine
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beta-Endorphin
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Clonidine