A group of 18 patients with clinically definite multiple sclerosis were subjected to alternate treatment with Prednisone (Polfa) and Decaris (Richter). The results were compared with those in a control group of 18 cases treated exclusively with Prednisone during exacerbations of the disease. The results indicate that the alternate treatment has not any significant effect on the course of multiple sclerosis, evaluated by the Kurtzke disability scale. The alternate treatment with a mild immunosuppression Encorton and immunomodulation-Decaris (Levamisole) leads to significant decrease of relapses in comparison with the period before the treatment, as well as in comparison with the control group treated exclusively with Encorton in case of exacerbations.