A glycine-mediated mixed-solvothermal approach has been proposed for the synthesis of novel Cu(2)O structures with different morphologies and the morphology effect on the antibacterial activity of the obtained Cu(2)O crystals has been studied, confirming that the obtained Cu(2)O crystals all show good antibacterial effects and that with the morphology of the Cu(2)O crystals changing from cubic to octahedral, the antibacterial property changes from general bacteriostasis to high selectivity.