Pathogenesis of bone and mineral related disorders in chronic kidney disease: key role of hyperphosphatemia

J Ren Care. 2009 Mar:35 Suppl 1:34-8. doi: 10.1111/j.1755-6686.2009.00050.x.

Abstract

This paper reviews the pathogenesis of hyperphosphataemia and its role in the regulation of parathyroid hormone synthesis and parathyroid cell proliferation in chronic kidney disease. The association between hyperphosphaemia and vascular calcification, and the interventions that can be used to control plasma phosphate are also discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aluminum Hydroxide / adverse effects
  • Aluminum Hydroxide / therapeutic use
  • Calcinosis / etiology
  • Calcitriol / physiology
  • Calcium / physiology
  • Chronic Kidney Disease-Mineral and Bone Disorder / etiology
  • Diet, Protein-Restricted / methods
  • Disease Progression
  • Humans
  • Hyperparathyroidism, Secondary / etiology
  • Hyperphosphatemia / diagnosis
  • Hyperphosphatemia / etiology*
  • Hyperphosphatemia / metabolism
  • Hyperphosphatemia / therapy*
  • Kidney Failure, Chronic / complications*
  • Kidney Failure, Chronic / therapy
  • Phosphorus / physiology
  • Phosphorus, Dietary / adverse effects
  • Renal Dialysis
  • Risk Factors
  • Vascular Diseases / etiology

Substances

  • Phosphorus, Dietary
  • Phosphorus
  • Aluminum Hydroxide
  • Calcitriol
  • Calcium