5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa

J Nat Prod. 2009 Apr;72(4):796-8. doi: 10.1021/np8007655.

Abstract

A new alkaloid, 5-bromo-8-methoxy-1-methyl-beta-carboline (1), has been isolated from the New Zealand marine bryozoan Pterocella Vesiculosa. Structural elucidation was achieved through NMR spectroscopic and mass spectrometric analysis, and a single-crystal X-ray diffraction analysis of 1 was performed. The biological activity of 1 was assessed against P388 murine leukemia cells and three microorganisms and compared with that of a number of related beta-carboline alkaloids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Bryozoa / chemistry*
  • Carbolines / chemistry
  • Carbolines / isolation & purification*
  • Carbolines / pharmacology
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Leukemia P388
  • Mice
  • Molecular Structure
  • New Zealand
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • 5-bromo-8-methoxy-1-methyl-beta-carboline
  • Alkaloids
  • Carbolines