Reconstruction of maxillary defects represents a major challenge for reconstructive surgeons. The authors describe two cases of malignant tumor on the maxilla that were successfully repaired using the immediate installation of prostheses supported with an Epitec-system during maxilla reconstruction. The Epitec-plates provided a strong retention source for the maxillodental prosthesis. To reduce the operation time and improve conformity to the remaining bone shape, a craniofacial skull model was fabricated using stereo-lithographic techniques. After trimming the model to simulate segmental resection, Epitec-plates were shaped to match the defect. A united Epitec-plate was fixed to the remaining bone immediately and easily after tumor resection. An immediate maxillary prosthesis was placed and was functional at the end of surgery. The Epitec-system provides effective materials for immediate prosthesis of extensive maxillary defects.