Stereoselective one-pot, three-component synthesis of 4-aryltetrahydropyran via Prins-Friedel-Crafts reaction

U C Reddy; S Bondalapati; Anil K Saikia

doi:10.1021/jo802531h

Stereoselective one-pot, three-component synthesis of 4-aryltetrahydropyran via Prins-Friedel-Crafts reaction

J Org Chem. 2009 Mar 20;74(6):2605-8. doi: 10.1021/jo802531h.

Authors

U C Reddy¹, S Bondalapati, Anil K Saikia

Affiliation

¹ Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India.

PMID: 19216514
DOI: 10.1021/jo802531h

Abstract

A diastereoselective one-pot, three-component Prins-Friedel-Crafts reaction was developed for the synthesis of 4-aryltetrahydropyran derivatives from the reaction of carbonyl compounds with homoallylic alcohol in the presence of arene promoted by boron trifluoride etherate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alcohols / chemistry
Boranes / chemistry
Pyrans / chemical synthesis*
Stereoisomerism

Substances

Alcohols
Boranes
Pyrans
boron trifluoride etherate