Abstract
Three unusual tiglic acid-containing cyclodepsipeptides, possessing the revised regioisomeric structures for largamides A-C (1-3), have been isolated from the marine cyanobacterium Lyngbya confervoides collected from southeastern Florida. The two-dimensional structures were determined by NMR spectroscopy and the absolute configurations by chiral HPLC analysis of degradation products. Compounds 1-3 are moderate inhibitors of mammalian elastase activity in vitro with IC(50) values ranging from 0.53 to 1.41 microM.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cattle
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Crotonates / analysis
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Cyanobacteria / chemistry*
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification*
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Depsipeptides / pharmacology
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Hemiterpenes
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
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Protease Inhibitors / chemistry
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Protease Inhibitors / isolation & purification*
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Protease Inhibitors / pharmacology
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Swine
Substances
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Crotonates
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Depsipeptides
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Hemiterpenes
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Plant Extracts
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Protease Inhibitors
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largamide A
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largamide C
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tiglic acid