Red yeast rice fermentation by selected Monascus sp. with deep-red color, lovastatin production but no citrinin, and effect of temperature-shift cultivation on lovastatin production

Appl Biochem Biotechnol. 2009 Aug;158(2):476-82. doi: 10.1007/s12010-009-8553-8. Epub 2009 Feb 12.

Abstract

Monascus pilosus NBRC4520 was selected for functional fermented food inoculation for its high lovastatin and low citrinin production with a deep-red color. For koji (mold rice) with high lovastatin production, separation of the growth phase and lovastatin production phase by shifting the temperature from 30 to 23 degrees C increased lovastatin production by nearly 20 times compared to temperature-constant cultivation. In addition, citrinin was not produced even in the lovastatin production phase, although the pigment was increased. With temperature-shift cultivation, 225 microg lovastatin/g dry koji was produced in 14 days without citrinin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products / metabolism*
  • Citrinin / biosynthesis
  • Fermentation*
  • Lovastatin / biosynthesis*
  • Monascus / growth & development*
  • Monascus / metabolism*
  • Temperature*

Substances

  • Biological Products
  • red yeast rice
  • Citrinin
  • Lovastatin