Targeting exofacial protein thiols with Gd(III) complexes. An efficient procedure for MRI cell labelling

Chem Commun (Camb). 2009 Feb 28:(8):893-5. doi: 10.1039/b820593k. Epub 2009 Jan 26.

Abstract

Cells display on the outer surface of the plasma membrane a large number of protein thiols that can be reversibly labelled with suitably designed Gd(III)-based contrast agents for cell tracking by MRI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / metabolism*
  • Cellular Structures / chemistry
  • Contrast Media / chemistry*
  • Contrast Media / metabolism
  • Gadolinium / chemistry*
  • Humans
  • K562 Cells
  • Macromolecular Substances*
  • Magnetic Resonance Imaging / methods
  • Molecular Structure
  • Proteins*
  • Staining and Labeling / methods*
  • Sulfhydryl Compounds / chemistry*

Substances

  • Contrast Media
  • Macromolecular Substances
  • Proteins
  • Sulfhydryl Compounds
  • Gadolinium