Narrowband magnetic particle imaging

IEEE Trans Med Imaging. 2009 Aug;28(8):1231-7. doi: 10.1109/TMI.2009.2013849. Epub 2009 Feb 10.

Abstract

The magnetic particle imaging (MPI) method directly images the magnetization of super-paramagnetic iron oxide (SPIO) nanoparticles, which are contrast agents commonly used in magnetic resonance imaging (MRI). MPI, as originally envisioned, requires a high-bandwidth receiver coil and preamplifier, which are difficult to optimally noise match. This paper introduces Narrowband MPI, which dramatically reduces bandwidth requirements and increases the signal-to-noise ratio for a fixed specific absorption rate. We employ a two-tone excitation (called intermodulation) that can be tailored for a high-Q, narrowband receiver coil. We then demonstrate a new MPI instrument capable of full 3-D tomographic imaging of SPIO particles by imaging acrylic and tissue phantoms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Animals
  • Computer Simulation
  • Ferric Compounds / chemistry*
  • Liver / anatomy & histology
  • Magnetics*
  • Mice
  • Nanoparticles / chemistry*
  • Phantoms, Imaging
  • Tomography / methods*

Substances

  • Ferric Compounds
  • ferric oxide