Seven-year discordance in age at onset in monozygotic twins with inherited prion disease (P102L)

Neuropathol Appl Neurobiol. 2009 Aug;35(4):427-432. doi: 10.1111/j.1365-2990.2009.01012.x. Epub 2009 Jan 21.

Authors

T Webb^{1

2}, S Mead^{1

2}, J Beck², J Uphill², S Pal^{1

2}, S Hampson¹, J D F Wadsworth², I Dalmau Mena², C O'Malley², S Wroe^{1

2}, A Schapira³, S Brandner², J Collinge^{1

2}

Affiliations

¹ National Prion Clinic, National Hospital for Neurology and Neurosurgery.
² MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology.
³ and University Department of Clinical Neurosciences, Royal Free & University College Medical School, London, UK.

PMID: 19207267
DOI: 10.1111/j.1365-2990.2009.01012.x

No abstract available

Publication types

Case Reports
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Age of Onset
Brain / metabolism
Brain / pathology
Creutzfeldt-Jakob Syndrome / metabolism
Diseases in Twins / epidemiology*
Diseases in Twins / genetics
Diseases in Twins / pathology
Environment
Female
Humans
Middle Aged
Pedigree
PrPSc Proteins / metabolism
Prion Diseases / epidemiology*
Prion Diseases / genetics
Prion Diseases / pathology
Prion Proteins
Prions / genetics
Sequence Analysis, DNA
Twins, Monozygotic*

Substances

PRNP protein, human
PrPSc Proteins
Prion Proteins
Prions

Grants and funding