A theoretical study on the vibroacoustic performance of a rectangular double-panel partition clamp mounted in an infinite acoustic rigid baffle is presented. With the clamped boundary condition taken into account by the method of modal function, a double Fourier series solution to the dynamic response of the structure is obtained by employing the weighted residual method (i.e., the Galerkin method). The double series solution can be considered as the exact solution of the problem, as the structural and acoustic-structural coupling effects are fully accounted for and the solution converges numerically. The accuracy of the theoretical predictions is checked against existing experimental data, with good agreement achieved. The influence of several key parameters on the sound isolation capability of the double-panel configuration is then systematically studied, including panel dimensions, thickness of air cavity, elevation angle, and azimuth angle of incidence sound. The present method is suitable for double-panel systems of finite or infinite extent and is applicable for both low- and high-frequency ranges. With these merits, the proposed method compares favorably with a number of other approaches, e.g., finite element method, boundary element method, and statistical energy analysis method.