Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells

Ho-Keun Kwon; Won Kyung Jeon; Ji-Sun Hwang; Choong-Gu Lee; Jae-Seon So; Jin-A Park; Byoung Seob Ko; Sin-Hyeog Im

doi:10.1016/j.canlet.2009.01.015

Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells

Cancer Lett. 2009 Jun 18;278(2):174-182. doi: 10.1016/j.canlet.2009.01.015. Epub 2009 Feb 8.

Authors

Ho-Keun Kwon¹, Won Kyung Jeon², Ji-Sun Hwang¹, Choong-Gu Lee¹, Jae-Seon So¹, Jin-A Park¹, Byoung Seob Ko², Sin-Hyeog Im³

Affiliations

¹ Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
² Department of Herbal Resources Research and Quality Control Team, Korea Institute of Oriental Medicine, 305-811 Daejeon, Republic of Korea.
³ Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea; Center for Distributed Sensor Network Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea. Electronic address: imsh@gist.ac.kr.

PMID: 19203831
DOI: 10.1016/j.canlet.2009.01.015

Abstract

Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / pharmacology*
CD8-Positive T-Lymphocytes / drug effects*
CD8-Positive T-Lymphocytes / immunology
Cell Line, Tumor
Cinnamomum zeylanicum*
Cyclooxygenase 2 Inhibitors / pharmacology
Hypoxia-Inducible Factor 1, alpha Subunit / antagonists & inhibitors
Intercellular Signaling Peptides and Proteins / analysis
Intercellular Signaling Peptides and Proteins / genetics
Male
Melanoma, Experimental / drug therapy*
Melanoma, Experimental / pathology
Mice
Mice, Inbred C57BL
Neovascularization, Pathologic / drug therapy*
Plant Extracts / pharmacology*

Substances

Antineoplastic Agents, Phytogenic
Cyclooxygenase 2 Inhibitors
Hif1a protein, mouse
Hypoxia-Inducible Factor 1, alpha Subunit
Intercellular Signaling Peptides and Proteins
Plant Extracts