Obesity is one of the cardiovascular disease' s risk factors, at the same time to affect the development of hypertension and other risk factors. Recently, physiology or pathophysiology functions of adipocyte have been elucidated. And the mechanism of development hypertension has been investigated from adipocyte standpoints. In particular, knowledge of cytokine by adipocyte and insulin resistance has been clear. On the other hand, as the population of obesity is on the increases by the change of our living habits, hypertensive prevalence increases in particularly middle-aged men. Hypertension with obesity is often refractory, and it is poor prognosis. We have to develop an effective therapy in hypertension with obese subjects and have to spread it.