Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension

Ai Saiga-Egusa; Koji Iwai; Toru Hayakawa; Yoshihisa Takahata; Fumiki Morimatsu

doi:10.1271/bbb.80189

Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension

Biosci Biotechnol Biochem. 2009 Feb;73(2):422-4. doi: 10.1271/bbb.80189. Epub 2009 Feb 7.

Authors

Ai Saiga-Egusa¹, Koji Iwai, Toru Hayakawa, Yoshihisa Takahata, Fumiki Morimatsu

Affiliation

¹ R&D Center, Nippon Meat Packers, Inc., Tsukuba, Ibaraki, Japan. a.egusa@nipponham.co.jp

PMID: 19202283
DOI: 10.1271/bbb.80189

Abstract

Chicken collagen hydrolysate was given to 15 mildly hypertensive subjects for 4 weeks. Blood pressure was significantly decreased by 11.8 mmHg (P<0.01). A reduction in plasma renin activity was observed in blood test after intake. A colony assay of endothelial progenitor cells in blood samples from non-smokers revealed an approximately 30% increase in the number of colonies.

Publication types

Clinical Trial

MeSH terms

Animals
Antihypertensive Agents / administration & dosage
Antihypertensive Agents / pharmacology*
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects
Chickens
Collagen / administration & dosage
Collagen / pharmacology*
Collagen / therapeutic use
Endothelium / cytology*
Female
Humans
Hypertension / blood
Hypertension / drug therapy*
Hypertension / pathology
Hypertension / physiopathology
Male
Middle Aged
Protein Hydrolysates / administration & dosage
Protein Hydrolysates / pharmacology*
Protein Hydrolysates / therapeutic use
Stem Cells / cytology
Stem Cells / drug effects*
Stem Cells / metabolism

Substances

Antihypertensive Agents
Protein Hydrolysates
Collagen