Four antioxidant treatments (none, 0.05% ascorbic acid, 0.01%alpha-tocopherol + 0.01% sesamol, and 0.05% ascorbic acid + 0.01%alpha-tocopherol + 0.01% sesamol) were applied to ground beef using either mixing or spraying method. The meat samples were placed on Styrofoam trays, irradiated at 0 or 2.5 kGy, and then stored for 7 d at 4 degrees C. Color, lipid oxidation, volatiles, oxidation-reduction potential (ORP), and carbon monoxide (CO) production were determined at 0, 3, and 7 d of storage. Irradiation increased lipid oxidation of ground beef with control and ascorbic acid treatments after 3 d of storage. alpha-Tocopherol + sesamol and ascorbic acid +alpha-tocopherol + sesamol treatments were effective in slowing down lipid oxidation in ground beef during storage regardless of application methods, but mixing was better than the spraying method. Irradiation lowered L*-value and a*-value of ground beef. Storage had no effect on lightness but redness decreased with storage. Ascorbic acid was the most effective in maintaining redness of ground beef followed by ascorbic acid +alpha-tocopherol + sesamol. Irradiation and storage reduced the b*-value of ground beef. Irradiation lowered ORP of ground beef regardless of antioxidants application methods, but ORP was lower in beef with mixing than spraying method. Beef sprayed with antioxidants produced more hydrocarbons and alcohols than the mixing application, but ascorbic acid +alpha-tocopherol + sesamol treatment was effective in reducing the amount of volatiles produced by irradiation. Therefore, mixing was better than the spraying method in preventing lipid oxidation and maintaining color of irradiated ground beef.