Molecular modeling studies of ABC transporters involved in multidrug resistance

Aina Westrheim Ravna; Georg Sager

doi:10.2174/138955709787316065

Molecular modeling studies of ABC transporters involved in multidrug resistance

Mini Rev Med Chem. 2009 Feb;9(2):186-93. doi: 10.2174/138955709787316065.

Authors

Aina Westrheim Ravna¹, Georg Sager

Affiliation

¹ Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway. Aina.W.Ravna@fagmed.uit.no

PMID: 19200023
DOI: 10.2174/138955709787316065

Abstract

Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

ATP-Binding Cassette Transporters / chemistry*
ATP-Binding Cassette Transporters / genetics*
ATP-Binding Cassette Transporters / metabolism
Animals
Base Sequence
Drug Resistance, Multiple / genetics*
Humans
Models, Molecular
Molecular Sequence Data

Substances

ATP-Binding Cassette Transporters