The importance of steroidomics in the study of neurodegenerative disease and ageing

Comb Chem High Throughput Screen. 2009 Feb;12(2):212-28. doi: 10.2174/138620709787315472.

Abstract

In this mini review, the importance of experimental steroidomics in the study of neurodegenerative disease and aging is discussed. Attention is focused on just one class of lipid which is based on the cyclopentanoperhydro-phenanthrene ring system. Experimental methods for steroidomic analysis are reviewed, and the potential to use these methods to diagnose disease and to gain a better understanding of neurodegenerative disorders is examined.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / metabolism*
  • Animals
  • Brain / metabolism
  • Humans
  • Hydroxycholesterols / analysis
  • Hydroxycholesterols / blood
  • Hydroxycholesterols / cerebrospinal fluid
  • Hydroxycholesterols / metabolism
  • Ketocholesterols / analysis
  • Ketocholesterols / blood
  • Ketocholesterols / cerebrospinal fluid
  • Ketocholesterols / metabolism
  • Mass Spectrometry / methods*
  • Molecular Structure
  • Neurodegenerative Diseases / metabolism*
  • Steroids / analysis*
  • Steroids / blood
  • Steroids / cerebrospinal fluid
  • Steroids / metabolism*

Substances

  • Hydroxycholesterols
  • Ketocholesterols
  • Steroids