Guided tissue regeneration is a common form of treatment in dentistry nowadays. The orthodontist will inevitably have to deal with patients needing such therapy more often in the future. This review of the literature addresses the question of whether and if so, how patients with these medical requirements can be treated. We have systematically reviewed the current literature for recommendations, guidelines and problems associated with this treatment. Our data evaluation led us to conclude that such treatment is possible, and that it delivers promising results. However, more basic research on this interdisciplinary therapy should be carried out to identify and reduce risks and offer the patient greater safety during orthodontic treatment.