Abstract
Key relationships between the intramolecular H-bond-derived backbone conformation and the bioactivity of the novel fat-accumulation inhibitor (-)-ternatin are examined by analyses of the NMR spectroscopic data and CD spectra of designed analogues. The results reveal that the beta-turn structure of (-)-ternatin is responsible for its potent fat-accumulation inhibitory effect against 3T3-L1 murine adipocytes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3-L1 Cells
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Adipocytes / cytology*
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Adipocytes / metabolism
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Animals
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Dietary Fats / antagonists & inhibitors*
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Flavonoids / chemistry*
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Flavonoids / pharmacology
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Lipid Metabolism / drug effects
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Magnetic Resonance Spectroscopy
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Mice
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Obesity / prevention & control*
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Structure-Activity Relationship
Substances
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Dietary Fats
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Flavonoids
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ternatin (flavonoid)