Mitochondria and aging: innocent bystanders or guilty parties?

K Tońska; A Sołyga; E Bartnik

doi:10.1007/BF03195653

Mitochondria and aging: innocent bystanders or guilty parties?

J Appl Genet. 2009;50(1):55-62. doi: 10.1007/BF03195653.

Authors

K Tońska¹, A Sołyga, E Bartnik

Affiliation

¹ Department of Genetics and Biotechnology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw, Poland.

PMID: 19193984
DOI: 10.1007/BF03195653

Abstract

There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. However, there is little evidence that these mutations could affect the functioning of aging tissues.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aging*
Animals
Apoptosis
DNA Mutational Analysis
DNA, Mitochondrial / genetics*
DNA, Mitochondrial / metabolism*
Disease Models, Animal
Gene Deletion
Humans
Mice
Mitochondria / genetics*
Mitochondria / metabolism*
Mutation
Oxidative Stress / genetics
Skin / pathology
Skin Aging*

Substances

DNA, Mitochondrial