Abstract
Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from the ethyl acetate extracts of a Streptomyces sp. after purification by column chromatography and RP-HPLC. Their structures were elucidated using X-ray crystallography (1) and NMR spectroscopy (2 and 3).
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology*
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Crystallography, X-Ray
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Drug Resistance, Bacterial / drug effects
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Drug Screening Assays, Antitumor
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Enterococcus faecium / drug effects
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Escherichia coli / drug effects
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Humans
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Klebsiella pneumoniae / drug effects
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pseudomonas aeruginosa / drug effects
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Pyrroles / chemistry
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Pyrroles / isolation & purification
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Pyrroles / pharmacology
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Streptococcus pneumoniae / drug effects
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Streptomyces / chemistry*
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Pyrroles
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neopyrrolomycin B
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neopyrrolomycin C
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neopyrrolomycin
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Vancomycin