Does type 2 diabetes influence the risk of oesophageal adenocarcinoma?

R E Neale; J D Doecke; N Pandeya; S Sadeghi; A C Green; P M Webb; D C Whiteman; Australian Cancer Study

doi:10.1038/sj.bjc.6604908

Does type 2 diabetes influence the risk of oesophageal adenocarcinoma?

Br J Cancer. 2009 Mar 10;100(5):795-8. doi: 10.1038/sj.bjc.6604908. Epub 2009 Feb 3.

Authors

R E Neale¹, J D Doecke, N Pandeya, S Sadeghi, A C Green, P M Webb, D C Whiteman; Australian Cancer Study

Collaborators

Australian Cancer Study:
David C Whiteman, Penelope M Webb, Adele C Green, Nicholas K Hayward, Peter G Parsons, David M Purdie

Affiliation

¹ Queensland Institute of Medical Research, Australia. Rachel.Neale@qimr.edu.au

Abstract

Since hyperinsulinaemia may promote obesity-linked cancers, we compared type 2 diabetes prevalence among oesophageal adenocarcinoma (OAC) patients and population controls. Diabetes increased the risk of OAC (adjusted odds ratio 1.59, 95% confidence interval (CI) 1.04-2.43), although the risk was attenuated after further adjusting for body mass index (1.32, 95% CI 0.85-2.05).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / epidemiology
Adenocarcinoma / etiology*
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / epidemiology
Carcinoma, Squamous Cell / etiology
Case-Control Studies
Diabetes Mellitus, Type 2 / complications*
Diabetes Mellitus, Type 2 / epidemiology
Esophageal Neoplasms / epidemiology
Esophageal Neoplasms / etiology*
Female
Humans
Male
Middle Aged
Odds Ratio
Prevalence
Registries
Risk Factors