We demonstrate efficient self phase modulation, as well as negligible nonlinear absorption, in low loss (<0.06 dB/cm), high index silica glass-based waveguides. Using approximately 1 ps pulses near 1560 nm we achieve a 1.5pi nonlinear phase shift in an integrated 45 cm long spiral waveguide with <60 W of peak input power, corresponding to a large nonlinearity (gamma) of 220 W(-1)km(-1). Further, we observe negligible nonlinear absorption for input intensities > 25 GW/cm(2). The high nonlinearity and low linear and nonlinear losses of these waveguides make them promising for nonlinear all-optical signal processing applications.