Deadly splicing: Bax becomes Almighty

Mol Cell. 2009 Jan 30;33(2):145-6. doi: 10.1016/j.molcel.2009.01.004.

Abstract

Activation of Bax and Bak by BH3-only molecules triggers mitochondrial apoptosis. In a recent issue of Molecular Cell, Fu et al. (2009) identify a constitutively active isoform of Bax, Baxbeta, whose activity is tightly controlled by the ubiquitin-proteasome system.

Publication types

  • Comment

MeSH terms

  • Alternative Splicing / physiology*
  • Apoptosis
  • Mitochondria / metabolism
  • Models, Biological
  • Proteasome Endopeptidase Complex / metabolism
  • Protein Isoforms / metabolism
  • Ubiquitins / metabolism
  • bcl-2-Associated X Protein / metabolism*

Substances

  • Protein Isoforms
  • Ubiquitins
  • bcl-2-Associated X Protein
  • Proteasome Endopeptidase Complex