Abstract
Activation of Bax and Bak by BH3-only molecules triggers mitochondrial apoptosis. In a recent issue of Molecular Cell, Fu et al. (2009) identify a constitutively active isoform of Bax, Baxbeta, whose activity is tightly controlled by the ubiquitin-proteasome system.
MeSH terms
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Alternative Splicing / physiology*
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Apoptosis
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Mitochondria / metabolism
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Models, Biological
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Proteasome Endopeptidase Complex / metabolism
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Protein Isoforms / metabolism
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Ubiquitins / metabolism
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bcl-2-Associated X Protein / metabolism*
Substances
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Protein Isoforms
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Ubiquitins
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bcl-2-Associated X Protein
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Proteasome Endopeptidase Complex