Abstract
The methanolic extract and its saponin fraction (methanol-eluted fraction) of the pericarps of Sapindus rarak DC. were found to suppress plasma triglyceride elevation in olive oil-treated mice. From the active fraction, three new acylated oleanane-type triterpene saponins, rarasaponins IV (1), V (2), and VI (3), were isolated. The structures of 1-3 were elucidated on the basis of chemical and spectroscopic evidence. The principle saponin constituents, hederagenin 3-O-alpha-L-arabinopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (4) and hederagenin 3-O-(3,4-di-O-acetyl-alpha-L-arabinopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (5), showed inhibitory effects on plasma triglyceride elevation at a dose of 200 mg/kg, per os.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acetylation
-
Animals
-
Carbohydrate Conformation
-
Carbohydrate Sequence
-
Chromatography, High Pressure Liquid
-
Chromatography, Thin Layer
-
Hypertriglyceridemia / blood
-
Hypertriglyceridemia / chemically induced*
-
Hypertriglyceridemia / drug therapy*
-
Hypolipidemic Agents / chemistry*
-
Hypolipidemic Agents / pharmacology
-
Magnetic Resonance Spectroscopy
-
Male
-
Mice
-
Molecular Sequence Data
-
Oleanolic Acid / analogs & derivatives*
-
Oleanolic Acid / chemistry
-
Oleanolic Acid / pharmacology
-
Olive Oil
-
Plant Bark / chemistry
-
Plant Oils
-
Sapindus / chemistry*
-
Saponins / chemistry*
-
Saponins / pharmacology*
-
Spectrometry, Mass, Fast Atom Bombardment
-
Spectrophotometry, Ultraviolet
-
Triglycerides / blood
-
Triterpenes / chemistry*
-
Triterpenes / pharmacology*
Substances
-
Hypolipidemic Agents
-
Olive Oil
-
Plant Oils
-
Saponins
-
Triglycerides
-
Triterpenes
-
rarasaponin IV
-
rarasaponin V
-
rarasaponin VI
-
Oleanolic Acid