[Influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients]

Zhong Yao Cai. 2008 Sep;31(9):1410-2.
[Article in Chinese]

Abstract

Objective: To study the influencing factors in preparation of brucine liposomes by ammonium sulfate transmembrane gradients.

Methods: The brucine liposomes were separated by Sephadex G-50, and the influence of various factors on the entrapment efficiencies were investigated.

Results: The entrapment efficiency was enhanced by increased ammonium sulfate concentration, ethanol volume and PC concentration.

Conclusion: Burcine liposomes prepared by ammonium sulfate transmembrance gradients can get a high entrapment efficiency, the main influencing factors were ammonium sulfate concentration, ethanol volume and PC concentration.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ammonium Sulfate / chemistry*
  • Area Under Curve
  • Drug Carriers
  • Drug Stability
  • Ethanol / chemistry
  • Hydrogen-Ion Concentration
  • Liposomes / chemistry*
  • Phospholipids / chemistry
  • Plants, Medicinal / chemistry
  • Quality Control
  • Strychnine / analogs & derivatives*
  • Strychnine / chemistry
  • Strychnos / chemistry*
  • Technology, Pharmaceutical
  • Temperature

Substances

  • Drug Carriers
  • Liposomes
  • Phospholipids
  • Ethanol
  • brucine
  • Strychnine
  • Ammonium Sulfate