Abstract
In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Basilar Artery / drug effects
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Basilar Artery / physiology*
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Curcumin / chemical synthesis*
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Curcumin / pharmacology
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Dose-Response Relationship, Drug
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In Vitro Techniques
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Male
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Molecular Mimicry* / physiology
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Rabbits
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Sulfinic Acids / chemical synthesis*
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Sulfinic Acids / pharmacology
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Vasodilation / drug effects
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Vasodilation / physiology*
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Vasodilator Agents / chemical synthesis
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Vasodilator Agents / pharmacology
Substances
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Sulfinic Acids
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Vasodilator Agents
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Curcumin