Abstract
Abatacept (CTLA4Ig) is a human fusion protein which consists of a cytotoxic lymphocytic-associated type 4 antigen which is bound to the Fc part of the IgG1. Abatacept binds to CD80/CD86 on antigen-presenting cells thus blocking the co-stimulatory signal to the naïve T cells and interfering with a central inflammatory rheumatoid arthritis signal pathway.
MeSH terms
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Abatacept
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Adult
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Antirheumatic Agents / administration & dosage
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Antirheumatic Agents / adverse effects
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Antirheumatic Agents / therapeutic use*
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Arthritis, Rheumatoid / drug therapy*
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Humans
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Immunoconjugates / administration & dosage
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Immunoconjugates / adverse effects
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Immunoconjugates / therapeutic use*
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / adverse effects
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Immunosuppressive Agents / therapeutic use*
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Treatment Outcome
Substances
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Antirheumatic Agents
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Immunoconjugates
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Immunosuppressive Agents
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Abatacept