An antiplasmodial new (bis)indole alkaloid from the hard coral Tubastraea sp

Nat Prod Res. 2009;23(2):178-82. doi: 10.1080/14786410801925134.

Abstract

Tubastarea sp., a stony coral (Dendrophylliidae) from the Great Hanish in the Archipelago of the Hanish Islands, Yemen, contains, in addition to the known aplysinopsin (1) and 6-bromo-3'-deimino-3'-oxoaplysinopsin (2), the new bis(indole) alkaloid (3). The structures of compounds (1-3) were elucidated by interpretation of spectral data. Compound 3 inhibits the growth of Plasmodium falciparum (chloroquine-resistant strain) with an IC(50) 1.2 microg mL(-1).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antimalarials / chemistry
  • Antimalarials / isolation & purification*
  • Antimalarials / pharmacology
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / isolation & purification*
  • Indole Alkaloids / pharmacology*
  • Mass Spectrometry
  • Nuclear Magnetic Resonance, Biomolecular
  • Optical Rotation
  • Plasmodium falciparum / drug effects
  • Plasmodium falciparum / growth & development
  • Spectrophotometry, Ultraviolet
  • Yemen

Substances

  • Antimalarials
  • Indole Alkaloids