Correlates and mediators of functional disability in obsessive-compulsive disorder

Depress Anxiety. 2009;26(9):806-13. doi: 10.1002/da.20481.

Abstract

Background: This study examined factors associated with obsessive-compulsive disorder (OCD) related functional disability in 87 treatment-seeking adults with OCD.

Methods: A trained evaluator administered the Yale-Brown Obsessive-Compulsive Scale and Brown Assessment of Beliefs Scale. Patients completed the Sheehan Disability Scale, Obsessive-Compulsive Inventory-Revised, Interpretation of Intrusions Inventory, Thought-Action Fusion Scale, Beck Depression Inventory Second Edition, and State Trait Anxiety Inventory-Trait Version.

Results: Results indicated that OCD symptoms, anxiety, depression, and the tendency to misinterpret the significance of intrusive thoughts were related to functional disability. Two variables-depressive symptoms and the extent to which a patient attempts to resist and is able to control OCD symptoms-emerged as unique predictors of functional disability. Mediational analyses indicated that both of these variables fully mediated the relationship between OCD-related distress and functional disability.

Conclusions: Results are discussed in terms of predictors of functional disability in OCD and in terms of implications for assessment and treatment.

MeSH terms

  • Adult
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / psychology
  • Comorbidity
  • Culture
  • Depressive Disorder / diagnosis
  • Depressive Disorder / psychology
  • Disability Evaluation*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Obsessive-Compulsive Disorder / diagnosis*
  • Obsessive-Compulsive Disorder / psychology
  • Personality Inventory / statistics & numerical data
  • Psychometrics