During recent years cardiac resynchronization has become an important tool in the treatment of patients with signs and symptoms of heart failure and desynchronized contraction of the left ventricle. Among patients with heart failure, right ventricular involvement can occur because the underlying disease affects both ventricles or because the reduction of left ventricular function impairs the right ventricular function by altered coupling and increased right ventricular afterload. Irrespective of the underlying cause the reduction of right ventricular function confers an adverse prognosis that is further aggravated by the presence of pulmonary hypertension. The present article describes the relevance of reduced right ventricular function for the clinical syndrome of heart failure, the role of right ventricular resynchronization in patients with predominant right heart failure and the possible effects of left ventricular resynchronization on a preexisting impairment of right ventricular function.