Rubiacordone A: a new anthraquinone glycoside from the roots of Rubia cordifolia

Molecules. 2009 Jan 23;14(1):566-72. doi: 10.3390/molecules14010566.

Abstract

A new anthraquinone, Rubiacordone A (1) (6-acetoxy-1-hydroxy-2-methylanthraquinone-3-O-alpha-L-rhamnopyranoside), was isolated together with the known anthraquinone, 1-acetoxy-6-hydroxy-2-methylanthraquinone-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside] (2), from the dried roots of Rubia cordifolia. Their structures were elucidated on the basis of extensive 1D and 2D-NMR, as well as HRESI-MS spectroscopic analysis. Metabolites 1 and 2 showed considerable antimicrobial activity against Gram-positive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthraquinones* / chemistry
  • Anthraquinones* / isolation & purification
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Glycosides* / chemistry
  • Glycosides* / isolation & purification
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Medicine, Chinese Traditional
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Extracts / chemistry*
  • Plant Roots / chemistry*
  • Rubia / chemistry*
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Anthraquinones
  • Anti-Infective Agents
  • Drugs, Chinese Herbal
  • Glycosides
  • Plant Extracts