The Salmonella pathogenicity island 2-encoded type III secretion system is essential for the survival of Salmonella enterica serovar Typhimurium in free-living amoebae

Appl Environ Microbiol. 2009 Mar;75(6):1793-5. doi: 10.1128/AEM.02033-08. Epub 2009 Jan 23.

Abstract

Free-living amoebae represent a potential reservoir and predator of Salmonella enterica. Through the use of type III secretion system (T3SS) mutants and analysis of transcription of selected T3SS genes, we demonstrated that the Salmonella pathogenicity island 2 is highly induced during S. enterica serovar Typhimurium infection of Acanthamoeba polyphaga and is essential for survival within amoebae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acanthamoeba / microbiology*
  • Animals
  • Gene Expression Profiling
  • Genes, Bacterial
  • Genes, Essential
  • Genomic Islands*
  • Membrane Transport Proteins / genetics
  • Membrane Transport Proteins / physiology*
  • Microbial Viability*
  • Mutation
  • Salmonella typhimurium / pathogenicity*
  • Virulence Factors / genetics
  • Virulence Factors / physiology*

Substances

  • Membrane Transport Proteins
  • Virulence Factors