Abstract
A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenylpyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / pharmacology
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Bacteria / drug effects
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Chloroquine / pharmacology
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Combinatorial Chemistry Techniques
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Drug Resistance / drug effects
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Ferrous Compounds / chemistry*
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Fungi / drug effects
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Imines / pharmacology
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Metallocenes
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Microbial Sensitivity Tests
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Molecular Structure
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Pyrazoles / chemical synthesis*
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Pyrazoles / chemistry
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Pyrazoles / pharmacology*
Substances
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Amines
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Anti-Bacterial Agents
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Antifungal Agents
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Ferrous Compounds
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Imines
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Metallocenes
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Pyrazoles
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Chloroquine
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ferrocene