Adaptive bone remodeling is an important factor that leads to bone resorption in the surrounding femoral bone and implant loosening. Taking into account this factor in the design of hip implants is of clinical importance, because it allows the prediction of the bone-density redistribution and enables the monitoring of bone adaptation after prosthetic implantation. In this article, adaptive bone remodeling around a new biomimetic polymer-composite-based (CF/PA12) hip prosthesis is investigated to evaluate the amount of stress shielding and bone resorption. The design concept of this new prosthesis is based on a hollow substructure made of hydroxyapatite-coated, continuous carbon fiber (CF)-reinforced polyamide 12 (PA12) composite with an internal soft polymer-based core. Strain energy density theory coupled with 3D Finite Element models is used to predict bone density redistributions in the femoral bone before and after total hip replacement (THR) using both polymer-composite and titanium (Ti) stems. The result of numerical simulations of bone remodeling revealed that the CF/PA12 composite stem generates a better bone density pattern compared with the Ti-based stem, indicating the effectiveness of the composite stem to reduce bone resorption caused by stress-shielding phenomenon. This may result in an extended lifetime of THR.