Cytotoxic guanidine alkaloids from Pterogyne nitens

J Nat Prod. 2009 Mar 27;72(3):473-6. doi: 10.1021/np800612x.

Abstract

As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Brazil
  • Drug Screening Assays, Antitumor
  • Fabaceae / chemistry*
  • Guanidines / chemistry
  • Guanidines / isolation & purification*
  • Guanidines / pharmacology*
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Plant Leaves / chemistry

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Guanidines
  • nitensidine D
  • nitensidine E