Abstract
We demonstrate that dispersion of single walled carbon nanotubes (SWNTs) by ultrasonication with phospholipid-polyethylene glycol (PL-PEG) fragments it, thus interfering with its ability to block nonspecific uptake by cells. However, unfragmented PL-PEG promoted specific cellular uptake of targeted SWNTs to two distinct classes of receptors expressed by cancer cells. Since fragmentation is a likely consequence of ultrasonication, a technique commonly used to disperse SWNTs, this maybe a concern for certain applications such as drug delivery.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism*
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Cell Line, Tumor
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ErbB Receptors / chemistry
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ErbB Receptors / metabolism*
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Folate Receptors, GPI-Anchored
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Humans
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Nanotubes, Carbon / chemistry*
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Neoplasms / metabolism*
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Neoplasms / pathology*
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Polyethylene Glycols / chemistry*
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Polyethylene Glycols / metabolism*
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / metabolism*
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Sensitivity and Specificity
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Substrate Specificity
Substances
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Carrier Proteins
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Folate Receptors, GPI-Anchored
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Nanotubes, Carbon
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Receptors, Cell Surface
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Polyethylene Glycols
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ErbB Receptors