Abstract
The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM(197) compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Cesarean Section
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Cytokines / biosynthesis
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Cytokines / genetics
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Drug Administration Schedule
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Female
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Humans
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Infant, Newborn
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Infant, Small for Gestational Age / immunology
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Papua New Guinea
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Pneumococcal Vaccines / administration & dosage
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Pneumococcal Vaccines / therapeutic use*
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Pregnancy
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Pregnancy Complications / immunology
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RNA, Bacterial / genetics
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RNA, Bacterial / isolation & purification
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Reverse Transcriptase Polymerase Chain Reaction
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Streptococcus pneumoniae / genetics
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology*
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Th2 Cells / immunology*
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Viral Vaccines / administration & dosage
Substances
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Cytokines
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Pneumococcal Vaccines
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RNA, Bacterial
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Viral Vaccines