Lymphomatoid granulomatosis of the uterine cervix

Pathol Res Pract. 2009;205(5):371-4. doi: 10.1016/j.prp.2008.11.004. Epub 2009 Jan 14.

Abstract

Lymphomatoid granulomatosis is an Epstein-Barr virus-driven lymphoproliferative disorder, usually with a prominent pulmonary involvement and occasional extrapulmonary manifestations. Here, we present a case of lymphomatoid granulomatosis confined to the uterine cervix at the initial diagnosis. The disease was preceded by an immunosuppressive condition, namely low-grade lymphoplasmacytic lymphoma treated with chemotherapy. This is the first report of lymphomatoid granulomatosis at this site and emphasizes that it can present at unusual sites, such as the female genital tract in immunosuppressed patients.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use
  • Epstein-Barr Virus Infections / complications
  • Female
  • Humans
  • Immunocompromised Host*
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphomatoid Granulomatosis / immunology*
  • Lymphomatoid Granulomatosis / metabolism
  • Lymphomatoid Granulomatosis / pathology
  • Neoplasms, Second Primary / immunology*
  • Neoplasms, Second Primary / pathology
  • Palatine Tonsil / metabolism
  • Palatine Tonsil / pathology
  • RNA, Viral / analysis
  • Uterine Cervical Neoplasms / immunology*
  • Uterine Cervical Neoplasms / metabolism
  • Uterine Cervical Neoplasms / pathology
  • Waldenstrom Macroglobulinemia / drug therapy
  • Waldenstrom Macroglobulinemia / pathology

Substances

  • Antineoplastic Agents
  • Epstein-Barr virus encoded RNA 2
  • RNA, Viral