This study sought to investigate carotid artery calcification (CAC) on panoramic radiographs from both healthy patients and those patients suffering from different chronic diseases. A total of 247 patients met the inclusion criteria and were reviewed. Ninety-two patients had one or more chronic diseases as indicated by their records; the remaining 155 patients had no mention of a chronic disease and were considered to be healthy controls. Among all patients, 13% had evidence of CAC, 21% of the patients with one or more chronic diseases had CAC, and only 8% of the patients in the control group had CAC. Those with liver disease only had the highest proportion (33%) of CAC.